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KMID : 0380620100420050586
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Korean Journal of Food Science and Technology
2010 Volume.42 No. 5 p.586 ~ p.592
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Effect of Stevia rebaudiana Bertoni Leaf Extract on Antiobesity in C57BL/6J Mice
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Park Jeong-Eun
Kee Hee-Jin
Cha Youn-Soo
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Abstract
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This study investigated the effects of Stevia rebaudian bertoni leaf extract on lipid profiles in C57BL/6J mice, as compared to stevioside. Fourty mice were divided into four groups: NC (normal diet and DW), HC (high fat diet and DW), HLSV (high fat diet and stevia leaf extract, 1 mL/kg/day), and HSS (high fat diet and stevioside, 1 mL/kg/day). Serum triglyceride concentrations were significantly lower in the HLSV and HSS groups than in the HC group.Epididymal fat pad weights were significantly lower in the HLSV and HSS groups than in the HC group. We also evaluated the serum and liver carnitine levels (NEC, AIAC, ASAC, TCNE) of all the groups. These results were supported by the mRNA expression of enzymes related to lipid metabolism (ACC, PPARα, ACS, CPT-I) assessed by RT-PCR. Overall, the results show the antiobesity effects of stevia leaf extract as compared to stevioside in high fat diet induced obese mice.
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KEYWORD
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Stevia rebaudian bertoni, stevioside, C57BL/6J mice, carnitine, antiobesity
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